Condition 1: Cervical ripening in pregnancy. Condition 2: Prolonged pregnancy. Condition 3: Failed medical induction of labour. Maternal care for other abnormalities of cervix Prolonged pregnancy Failed medical induction of labor
Conditions
Interventions
Intervention 1: Intervention group: Two capsules of 50 mg isosorbide-5-mononitrate were inserted in the posterior vaginal fornix in two consecutive days (50 mg per day). Intervention 2: Control group:
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Pregnant Gestational age of 39 - 41 weeks Intact membrane Bishop Score < 6 Singleton Cephalic presentation Maternal age between 18- 40 years old
Exclusion criteria
Exclusion criteria: Anti-hypertensive therapy Fetal death Known hypersensitivity to isosorbide mononitrate Aortic stenosis Obstructive myocardial hypertrophy Systolic blood pressure< 95 mm Hg Cardiovascular collapse
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bishop scores 48 hours after intervention. Timepoint: 48 hours after intervention. Method of measurement: Vaginal examination. | — |
Secondary
| Measure | Time frame |
|---|---|
| Frequency of vaginal delivery. Timepoint: At birth. Method of measurement: Data sheets.;Gestational age at the onset of spontaneous labor. Timepoint: Onset of spontaneous labor. Method of measurement: Data sheets.;Interval between intervention to delivery. Timepoint: At delivery. Method of measurement: Data sheets. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMaryam Kashanian
Ilam University of Medical Sciences
Outcome results
None listed