Condition 1: preterm birth, Preterm delivery, preterm uterine contractions, preterm labor. Condition 2: preterm birth, Preterm delivery, preterm uterine contractions, preterm labor. Condition 3: preterm birth, Preterm delivery, preterm uterine contractions, preterm labor. Preterm labour and delivery Preterm spontaneous labour with preterm delivery Preterm labor without delivery
Conditions
Interventions
Intervention 1: Intervention group: group A
100 mg rectal indomethacin was administered along with an oral placebo. If the patient responded to the initial treatment after two hours, 25 mg of oral indomethacin was administered every 4 hours plu
20 mg oral nifedipine was administered along with a rectal placebo. After 90 minutes, more 20 mg of oral nifedipine was administered. In case of responding to the initial treatment, 20 mg of oral nife
a combination of rectal indomethacin and oral nifedipine was administered per protocol as mentioned above.
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: gestational age of 26 to 34 weeks singleton uterine contractions with a frequency of at least 4 forceful uterine contractions per 20 minutes or a cervical dilatation of minimum 1 cm and minimum 50% cervical effacement.
Exclusion criteria
Exclusion criteria: rupture of membrane intrauterine fetal death cervical dilatation of more than 5 cm multiple pregnancy receiving tocolytic within past 24 hours polyhydramnios preeclampsia and eclampsia vaginal bleeding more than bloody show any maternal and fetal condition that contradict with receiving tocolitics severe fetal anomalies contradict fetal life fetal distress
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Inhibiting uterine contractions for 48 hours. Timepoint: 48 hours after intervention. Method of measurement: contraction monitoring by tocometer.;Delivery before 37 weeks of gestation. Timepoint: Birth date. Method of measurement: Data sheets. | — |
Secondary
| Measure | Time frame |
|---|---|
| Inhibiting the contractions in the first 2 hours after intervention. Timepoint: 2 hours after intervention. Method of measurement: Tocometer.;Delivery within 7 days after intervention. Timepoint: 7 days after intervention. Method of measurement: Birth date.;Gestational age at the time of birth. Timepoint: time of birth. Method of measurement: birth date.;Duration of prolongation of pregnancy. Timepoint: birth date. Method of measurement: Data sheets. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMaryam Kashanian
Iran University of Medical Sciences
Outcome results
None listed