The effects of sildenaphil on oligohydramnios

Evaluation of the effects of sildenaphil on oligohydramnios in pregnant women.

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20091023002624N21

Enrollment

190

Registered

2017-12-17

Start date

2017-12-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Oligohydramnios. Oligohydramnios

Interventions

Intervention 1: Intervention group: sildenafil ( 25 milligram every 8 hours) plus 2 liter intravenous hydration( 250 milliliter/ hour every 4 hours isotonic solution) will be prescribed. Intervention

Treatment - Drugs

Placebo

Intervention group: sildenafil ( 25 milligram every 8 hours) plus 2 liter intravenous hydration( 250 milliliter/ hour every 4 hours isotonic solution) will be prescribed.

Control group: control group will receive placebo plus 2 liter intravenous hydration( 250 milliliter/ hour every 4 hours isotonic solution).

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Informed consent Singleton pregnancy Gestational age 30-37 weeks Amniotic fluid index (AFI) less than 5 cm which was discoveredduring third-trimester ultrasonography

Exclusion criteria

Exclusion criteria: Abnormal fetal Doppler Fetal anomalies Fetal growth restriction Fetal distress like nonreactive non stress test(NST) Maternal chronic hypertension Pre-gestational diabetes, Active labor Rupture of membranes Treatment with prostaglandin synthase inhibitors Maternal diseases contraindicating bolus fluid therapy (kidney, lung, or heart disease)

Design outcomes

Primary

Measure	Time frame
Increasing in amniotic fluid index. Timepoint: at 6 weeks of intervention or before delivery, whichever occurs first. Method of measurement: ultrasonogram.	—

Secondary

Measure	Time frame
Gestational age at delivery. Timepoint: Delivery. Method of measurement: Data sheets.;Rout of delivery. Timepoint: Delivery. Method of measurement: Data sheets.;Neonatal weight. Timepoint: At birth. Method of measurement: Data sheets, gram.;Neonatal Apgar score. Timepoint: At 1 and 5 minutes after birth. Method of measurement: Data sheets.;Umbilical artery pH. Timepoint: at birth. Method of measurement: Data sheets.;Admission to NICU. Timepoint: any time after birth. Method of measurement: Data sheets.;Length of NICU stay. Timepoint: After discharge. Method of measurement: Data sheets, Days.	—

Measure

Time frame

Gestational age at delivery. Timepoint: Delivery. Method of measurement: Data sheets.;Rout of delivery. Timepoint: Delivery. Method of measurement: Data sheets.;Neonatal weight. Timepoint: At birth. Method of measurement: Data sheets, gram.;Neonatal Apgar score. Timepoint: At 1 and 5 minutes after birth. Method of measurement: Data sheets.;Umbilical artery pH. Timepoint: at birth. Method of measurement: Data sheets.;Admission to NICU. Timepoint: any time after birth. Method of measurement: Data sheets.;Length of NICU stay. Timepoint: After discharge. Method of measurement: Data sheets, Days.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Kashanian

Iran University of Medical Sciences

maryamkashanian@yahoo.com+98 21 5563 3244

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026