Major depressive disorder. Major depressive disorder, recurrent, mild
Conditions
Interventions
Intervention 1: The intervention group receive Modafinil for eight weeks in addition to standard antidepressant medication with SSRIs or SNRIs. The drug is initially administered for one week at dose
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Confirmed history of major depressive disorder based on the DSM-5 criteria, now in the recovery phase and receiving SSRIs or SNRIs Beck Depression Inventory score less than 28 18 to 40 years old The patient has not had more than three episodes Mean score of 30 for positive affect and 15 for negative affect on Positive and Negative Affect Schedule (PANAS) test Completing the informed consent form
Exclusion criteria
Exclusion criteria: Suffering any other major psychiatric illnesses Thyroid, immunological or neurological problems and other contraindications to Modafinil (such as refractory hypertension or history of cardiac arrhythmia) based on clinical history Mental retardation History of head injury or substance abuse
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Working memory capacity, measured by Persian word/non word span test. Timepoint: weeks 0, 2, 4 & 8 of drug administration. Method of measurement: Persian word/non word span test. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammad Reza Fayyazi Bordbar
Mashhad University of Medical Sciences
Outcome results
None listed