Evaluation of Fixed versus Flexible Gonadotropin Releasing Hormone Antagonist Protocol for In vitro Fertilization in Women with Polycystic Ovary Syndrome

Evaluation and comparison of Fixed versus Flexible Gonadotropin Releasing Hormone Antagonist Protocol in Controlled Ovarian Stimulation for In vitro Fertilization in Women with Polycystic Ovary Syndrome- A randomized clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20091018002604N6

Enrollment

150

Registered

2023-10-09

Start date

2023-10-12

Completion date

Unknown

Last updated

2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility. Female infertility

Interventions

Intervention 1: Intervention group 1: (Fixed group) on the second day of the menstrual cycle, ultrasound will be performed and 150 IU rFSH gonadotropin will be injected daily . Then, starting from th

Eligibility

Sex/Gender

Female

Age

20 Years to 40 Years

Inclusion criteria

Inclusion criteria: Women with Polycystic Ovary Syndrome (PCOS) candidate for ART(Assisted Reproductive Techniques) Age in range of 20-40 years BMI in range of 20-30 kg/m2

Exclusion criteria

Exclusion criteria: Sever endometriosis Sever male factor infertility Pelvic neoplasia

Design outcomes

Primary

Measure	Time frame
The number of M II oocytes. Timepoint: After ovarian puncture. Method of measurement: Microscopic manual counting by embryologist.	—

Secondary

Measure	Time frame
The number of embryos with qualities of A,B,or C. Timepoint: 1-2 days after ovarian puncture. Method of measurement: Microscopic manual counting by embryologist.;The duration of controlled ovarian stimulation period. Timepoint: Immediatly after controlled ovarian stimulation. Method of measurement: Time scale(day).;The dosage of Gonadotropin used. Timepoint: After controlled ovarian stimulation. Method of measurement: Counting.;The number of Cetrotide injections. Timepoint: After controlled ovarian stimulation. Method of measurement: Counting.;The incidence of OHSS(Ovarian Hyperstimulation Syndrome). Timepoint: 3_7 days after trigger. Method of measurement: Through phisycal examination and Ultra sonography.	—

Measure

Time frame

The number of embryos with qualities of A,B,or C. Timepoint: 1-2 days after ovarian puncture. Method of measurement: Microscopic manual counting by embryologist.;The duration of controlled ovarian stimulation period. Timepoint: Immediatly after controlled ovarian stimulation. Method of measurement: Time scale(day).;The dosage of Gonadotropin used. Timepoint: After controlled ovarian stimulation. Method of measurement: Counting.;The number of Cetrotide injections. Timepoint: After controlled ovarian stimulation. Method of measurement: Counting.;The incidence of OHSS(Ovarian Hyperstimulation Syndrome). Timepoint: 3_7 days after trigger. Method of measurement: Through phisycal examination and Ultra sonography.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactHanieh Fatehi

Yazd University of Medical Sciences

dr.fatehi435@gmail.com+98 35 3824 7085

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026