Comparison of topical ?% Methimazole and 4 % Hydroquinone effect on melasma

Comparison of the effect of topical Methimazole 5% versus topical Hydroquinone 4% on the improvement of melasma lesions

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20091012002581N9

Enrollment

Registered

2023-02-21

Start date

2023-03-06

Completion date

Unknown

Last updated

2023-03-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

melasma. Chloasma

Interventions

Intervention 1: Intervention group: 5% topical methymazole cream that has been formulated in Tabriz University of Medical Sciencses Faculty of Pharmacy, is provided to the patients and they are asked

Eligibility

Sex/Gender

All

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Age higher than 18 years and below 50 years Informed consent participate in the study Presence of melanoma in both sides of cheeks

Exclusion criteria

Exclusion criteria: Lack of consent to participate in the study Pregnancy or lactation History of sensitivity to Tiamazoles Thyroid dysfunction History of using other topical drugs for melanoma in past 3 months

Design outcomes

Primary

Measure	Time frame
Severity of melasma lesions. Timepoint: 1, 4, 8 and 12 months after treatment. Method of measurement: Clinical examination and comparison of photos and use of Hemi Masi score.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Hamideh Herizchi- Ghadim

Tabriz University of Medical Sciences

dr.herizchi@yahoo.com+98 41 1540 6612

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026