Localized morphea. Localized scleroderma [morphea]
Conditions
Interventions
Intervention 1: Intervention group: 10 people with localized morphea will be treated with topical ointment fluocinolone and tacrolimus 0.1 percent every 12 hours for 4 months. Intervention 2: Control
Sponsors
Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The disease is in its active phase Patients have not received any treatment in the past 6 weeks Existence of at least one morphea plaque with a total area of cm2 10 Lack of use of immunosuppressants, penicillamine, interferon gamma, or phototherapy in the last three months
Exclusion criteria
Exclusion criteria: Systemic sclerosis or pseudosclerosis Existence of a history of side effects in previous use of tacrolimus (hypersensitivity, intolerance) Contraceptive radiation therapy Pregnant women or those who are planning to become pregnant during treatment Breastfeeding women Infectious active lesion at the site of morphea plaque Recent vaccinations (28 days before the start of the study) Borrelia burgdorferi infection (serological diagnosis)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Morphea waste area. Timepoint: Months 0 -2- 4. Method of measurement: Measurement with ruler.;Dispigmentation. Timepoint: Months 0 -2- 4. Method of measurement: 16 megapixel digital camera from a distance of 10 cm from the lesion.;Hardness. Timepoint: Months 0 -2- 4. Method of measurement: Observe and pinch through the lesion.;Atrophy. Timepoint: Months 0 -2- 4. Method of measurement: View and touch as well as digital camera. | — |
Secondary
| Measure | Time frame |
|---|---|
| Patient satisfaction after treatment. Timepoint: Months 0- 2- 4. Method of measurement: Patient serial examination - questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Hamide Herizchi Ghadim
Tabriz University of Medical Sciences
Outcome results
None listed