The effect of exosomes on recurrent implantation failure (RIF)

Investigating the effect of intrauterine exosome injection on pregnancy outcomes in infertile women candidates for IVF and repeated implantation failure

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20091012002576N44

Enrollment

Registered

2024-06-23

Start date

2024-07-05

Completion date

Unknown

Last updated

2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Recurrent implantation failure. Female infertility, unspecified

Interventions

Intervention 1: Intervention group: ? After eight days of estrogen 6 mg daily, exosomes 100 micro liter will be injected into uterine cavity by IUI catheter, for RIF. Intervention 2: Control group: Th

Eligibility

Sex/Gender

Female

Age

20 Years to 37 Years

Inclusion criteria

Inclusion criteria: History of recurrent implantation failure due to unknown etiology Having good quality mbryo age 20-37y

Exclusion criteria

Exclusion criteria: Uterine malformations Asherman syndrome Liver diseas Severe male infertility Body mass index(BMI)>30 Uncontrolled hypothyroidism

Design outcomes

Primary

Measure	Time frame
Endometrial thickness and quality. Timepoint: Two days after intervention. Method of measurement: Transvaginal sonogram.	—

Secondary

Measure	Time frame
Chemical pregnancy. Timepoint: ?Two weeks after embryo transfer. Method of measurement: Bhcg measurement.;Clinical pregnancy. Timepoint: Four weeks after embryo transfer. Method of measurement: Transvaginal sonogram.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFatemeh Davari Tanha

Tehran University of Medical Sciences

Fatedavtanha@gmail.com+98 21 8880 0115

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026