Comparison of Assisted Hatching effect on IVF/ICSI outcome in patients with poor ovarian response according to POSEIDON criteria

Comparison of Assisted Hatching effect on IVF/ICSI outcome in patients with poor ovarian response according to POSEIDON criteria; a randomized clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20091012002575N5

Enrollment

170

Registered

2023-12-06

Start date

2024-01-06

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility. Female infertility associated with anovulation

Interventions

Intervention 1: Intervention group: laser hatching operation (using a laser to pierce the shingles). Intervention 2: Control group: no laser hatching operation.

Eligibility

Sex/Gender

Female

Age

18 Years to 42 Years

Inclusion criteria

Inclusion criteria: Candidates for fresh or frozen-thawed embryo transfer with poor ovarian response classified as POSEIDON groups three and four Age between 18 and 42 years

Exclusion criteria

Exclusion criteria: Structural anomalies of uterus Poor quality embryos Severe male factor

Design outcomes

Primary

Measure	Time frame
Clinical pregnancy. Timepoint: Four weeks after embryo transfer. Method of measurement: Fetal heart beat detection by ultrasound.	—

Secondary

Measure	Time frame
Chemical pregnancy. Timepoint: 2 weeks after embryo transfer. Method of measurement: Serum Beta HCG titer.;Implantation rate. Timepoint: 4 weeks after embryo transfer. Method of measurement: Number of intrauterine gestational sacs on ultrasound divided by the number of transferred embryos.;Ongoing pregnancy. Timepoint: 12 weeks post embryo transfer. Method of measurement: Continued presence of fetal cardiac activity.;Multiple pregnancy rate. Timepoint: 4 weeks after embryo transfer. Method of measurement: Number of gestational sacs containig fetal pole on ultrasound.;Early abortion. Timepoint: 12 weeks after embryo transfer. Method of measurement: Absence of gestational sac or fetal heartbeat in ultrasound.	—

Measure

Time frame

Chemical pregnancy. Timepoint: 2 weeks after embryo transfer. Method of measurement: Serum Beta HCG titer.;Implantation rate. Timepoint: 4 weeks after embryo transfer. Method of measurement: Number of intrauterine gestational sacs on ultrasound divided by the number of transferred embryos.;Ongoing pregnancy. Timepoint: 12 weeks post embryo transfer. Method of measurement: Continued presence of fetal cardiac activity.;Multiple pregnancy rate. Timepoint: 4 weeks after embryo transfer. Method of measurement: Number of gestational sacs containig fetal pole on ultrasound.;Early abortion. Timepoint: 12 weeks after embryo transfer. Method of measurement: Absence of gestational sac or fetal heartbeat in ultrasound.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactRazeyeh Dehghani Firouzabadi

Yazd University of Medical Sciences

dr_firouzabadi@ssu.ac.ir+98 35 4281 5807

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026