hypothermia. Hypothermia
Conditions
Interventions
Intervention group: 42 patients with severe brain damage will be included in the study, and as much as possible, in order to reduce confounding factors, people with relatively similar conditions (Glas
Sponsors
Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: ) age between 18-752) Severe brain damage3) Decreased level of consciousness (Glasgow coma score =8)4) Continuous control of body temperature5) Ethical consent from the first degree companion of the patient
Exclusion criteria
Exclusion criteria: 1) Patients who have problems in terms of surgery and have intra-visceral and mediastinal bleeding.2) head trauma patients who have parenchymal bleeding.3) Patients who have irreversible coagulopathy.4) Sepsis patients5) Lack of accompanying consent6 (Pregnant women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improving the performance of trauma patients one month and six months after discharge. Timepoint: Upon discharge, one month after discharge, six months after discharge. Method of measurement: A total of 42 patients with severe brain injury will enter the study. To minimize confounding factors, we will place individuals with relatively similar conditions (Glasgow scores and CPC scores close to each other) into two different groups. All individuals in both groups will receive sodium thiopental at a dose of 2.5 kg/mg intravenously every 15 minutes, up to 4 doses, followed by a continuous infusion of 5 hr/kg/mg intravenously for 3 hours, and then 2 hr/kg/mg intravenously continuously. The body temperature of the first group will be maintained at normothermia (36-37 degrees Celsius), while the body temperature of the second group will be maintained at hypothermia (34-35 degrees Celsius). This will be carried out for 72-96 hours, after which we will interpret the results. During the hypothermia induction process, we must ensure the comfort and pain relief of the patients. To prevent shivering due to hypothermia, we will use analgesics (such as intravenous pethidine), sedatives, magnesium sulfate intravenously at a dose of 4 grams daily, and non-depolarizing muscle relaxants. Patient assessments will be conducted using the CPC Scale (Cerebral Performance Categories Scale).Blood cultures in these patients are necessary due to the use of phenobarbital and the potential immunosuppression it causes, to check for microbial infections. Routine blood tests for TSH, FT4, T3, T4, and vitamin D, B levels, along with CBC and UA/C, will be performed daily. Information regarding the nutritional factors and supplements received by patients during their hospital stay will be recorded. In this study, the body mass index (BMI) will be estimated for all patients under study, along with serum albumin levels and those vitamins and minerals identified through routine hospital tests.It is impor | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHassan Soleimanpour
Tabriz University of Medical Sciences
Outcome results
None listed