Effect of Vitamin C on adrenal suppression following etomidate for rapid sequence induction in trauma patients

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20090923002496N11

Enrollment

Registered

2019-04-19

Start date

2019-05-22

Completion date

Unknown

Last updated

2019-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Rapid sequence induction/ intubation. Condition 2: Adrenal suppression. Drug-induced adrenocortical insufficiency

Interventions

Intervention 1: Intervention group: A single dose of one gram of intravenous Vitamin C will be used. The drug we will use in this study is made by Sobhan pharmaceutical Co. Iran. Intervention 2: Contr

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Traumatic patients who need rapid sequence induction/ intubation More than 18 year old

Exclusion criteria

Exclusion criteria: Corticosteroids users Pregnant patients history of endocrine disorders history of hepatic disorders history of renal disorders

Design outcomes

Primary

Measure	Time frame
Blood cortisol level. Timepoint: Prior to and three hours after to etomidate injection. Method of measurement: Blood serum cortisol level measurement as nano-moles / liter.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHassan Soleimanpour

Tabriz University of Medical Sciences

soleimanpourh@tbzmed.ac.ir+98 41 3335 2078

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 9, 2026