Effects of prostaglandin and clomiphene citrate on pregnancy outcome

Adding Prostaglandin to Clomiphene Citrate in Mild Ovarian Stimulation Protocol in those Undergoing Intrauterine Insemination; A Randomized, Double-Blind, Clinical Trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20090912002445N8

Enrollment

106

Registered

2019-07-31

Start date

2018-05-22

Completion date

Unknown

Last updated

2019-10-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility. Female infertility associated with male factors

Interventions

Intervention 1: Intervention group: Clomiphene citrate (100mg daily from day 5 to 9 of menstrual cycle), gonadotropin (75 IU subcutaneously from day 8 to 11 of menstrual cycle), misoprostol (100mg twi

Eligibility

Sex/Gender

Female

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Patients with primary and secondary infertility Age between 18 and 45 years Candidates for mild ovarian stimulation and intrauterine insemination (IUI)

Exclusion criteria

Exclusion criteria: Sensitivity to prostaglandins Medical history of hepatic or renal diseases Polycystic ovarian syndrome (PCOS) Not having consent for inclusion in the study

Design outcomes

Primary

Measure	Time frame
Pregnancy Rate. Timepoint: 14 weeks. Method of measurement: Chemical Beta-HCG test.	—

Secondary

Measure	Time frame
Number of Dominant Follicle. Timepoint: 14 days. Method of measurement: Transvaginal Sonography.;Endometrial thinkness. Timepoint: 14 days. Method of measurement: Transvaginal sonography.;Side effects. Timepoint: 1 month. Method of measurement: Adverse effects form.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactPegah Keramati

Shiraz University of Medical Sciences

keramati@hotmail.com+98 71 3227 9701

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026