Morphine and methadone for postoperative pain control

Effects of Intraoperative Morphine and Methadone on Postoperative Pain Control in Opioid Addicted Patients undergoing Orthopedic Surgery

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20090912002445N7

Enrollment

Registered

2018-05-21

Start date

2016-10-01

Completion date

Unknown

Last updated

2018-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

After surgery pain. Pain, not elsewhere classified

Interventions

Intervention 1: Intervention group: Intramuscular methadone (0.15 mg/kg) one hour before termination of surgery. Intervention 2: Control group: Intramuscular morphine sulphate (0.15 mg/kg) one hour be

Eligibility

Sex/Gender

All

Age

18 Years to 78 Years

Inclusion criteria

Inclusion criteria: ASA Class I and II Opium Addict Elective orthopedic surgery

Exclusion criteria

Exclusion criteria: ASA Class III and IV Preoperative antidepressant and anticoagulant medication Hypersensitivity to morphine Hypersensitivity to methadone

Design outcomes

Primary

Measure	Time frame
Postoperative pain. Timepoint: 0, 1, 3, 6, 12, 24 hours after operation. Method of measurement: Visual analogue scale.;Postoperative nausea and vomitting. Timepoint: 0, 1, 3, 6, 12, 24 hours after operation. Method of measurement: Visual analogue scale.	—

Secondary

Measure	Time frame
Need for rescue analgesia. Timepoint: 24 hours after the surgery. Method of measurement: Administered dosage in milligrams.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactReza Raeesi Estabragh

Shiraz University of Medical Sciences

r.raeesi@yahoo.com+98 71 3647 4270

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026