Effects of Ondansetron and Clonazepam on Nausea and Vomiting after Laparoscopic Cholecystectomy

Effects of Preoperative Ondansetron and Clonazepam on Postoperative Nausea and Vomiting after Laparoscopic Cholecystectomy; A Randomized Double-Blind, Placebo Controlled Trial

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20090912002445N6

Enrollment

Registered

2018-01-22

Start date

2018-01-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Laparoscopic cholecystectomy.

Interventions

Intervention 1: Intervention group: 2 mg of oral clonazepam (Sobhan Darou Inc., rasht, Iran) and intravenous injection of placebo 15-minute prior to induction of anesthesia. Intervention 2: Interventi

Treatment - Drugs

Placebo

Intervention group: 2 mg of oral clonazepam (Sobhan Darou Inc., rasht, Iran) and intravenous injection of placebo 15-minute prior to induction of anesthesia.

Intervention group: 4 mg intravenous injection of ondansetron (Alborz Darou Inc, Tehran, Iran) and oral tablets of placebo

Control group: oral and intravenous injection of placebo

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: between 18 and 65 years of age. Having American Society of Anesthesiologists (ASA) physical status of I or II

Exclusion criteria

Exclusion criteria: Patients with body mass index (BMI) more than 30 kg/m2 history of previous severe Post-Operative Nausea and Vomiting (PONV) history of motion sickness significant gastrointestinal problems recent antiemetic drugs consumption smokers impaired kidney or liver functions and menstruating pregnant or lactating females migraine or cluster headaches mental retardation psychiatric disorder chronic alcohol consumption

Design outcomes

Primary

Measure	Time frame
Nausea`. Timepoint: 1, 3, 6, 12 and 24 hours after the operation. Method of measurement: 10-measure visual analogue scale (VAS).;Severity of pain. Timepoint: 1, 3, 6, 12 and 24 hours after the operation. Method of measurement: 10-measure visual analogue scale (VAS).;Vomiting. Timepoint: First 12 hours after the operation. Method of measurement: Record of vomiting incidence.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactReza Raeesi Estabragh

Shiraz University of Medical Sciences

r.raeesi@yahoo.com+98 71 3647 4270

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026