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The effect of diclofenac on the treatment of fever in children

Comparison of the effect of rectal diclofenac and high dose rectal acetaminophen on fever among children

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20090909002438N3
Enrollment
90
Registered
2019-07-04
Start date
2019-06-22
Completion date
Unknown
Last updated
2019-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fever. Fever, unspecified

Interventions

Intervention 1: Control group: These children will receive acetaminophen suppository at a dose of 30 mg / kg. The acetaminophen suppositories 125 and 325 mg are manufactured by Daroupakhsh Pharmaceuti
and then will be used. The rectal temperature of the patients will be measured before and then, one and three hours after the intervention, using the Beurer Digital Thermometer, FT15 / 1, manufactured

Sponsors

Guilan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
1 Years to 6 Years

Inclusion criteria

Inclusion criteria: Age of 1 to 6 years old at least 10 kg weight Fever between 39-40.5 ° C of rectal temperature lasted for less than 4 days

Exclusion criteria

Exclusion criteria: Diarrhea in the last 24 hours History of previous sensitivity to acetaminophen and diclofenac History of malignancy History of renal failure History of liver failure History of neurological disease or febrile convulsion within the past hour, or loss of consciousness or known vasculitis Use of antipyretic over the past 8 hours Use of antibiotics within the past 8 hours or 3 hours after the administration of the active antipyretic drug (acetaminophen or diclofenac) History of Hyper Reactive Airway Disease History of gastritis and peptic ulcer

Design outcomes

Primary

MeasureTime frame
Rate of patient temperature. Timepoint: Measure the temperature of the patients before, one and three hours after the intervention. Method of measurement: Digital rectal thermometer.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHouman Hashemian

Guilan University of Medical Sciences

hashemian@gums.ac.ir+98 13 3336 9002

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026