end stage of renal disease. End stage renal disease
Conditions
Interventions
Intervention 1: Intervention group: Concentrated pomegranate syrup, 2 tablespoons per day (total equivalent to 20 grams), for 10 weeks, produced by Sanabol Daru Company. Intervention 2: Control group:
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
25 Years to 60 Years
Inclusion criteria
Inclusion criteria: Age 30-60 years BMI 30-18.5 At least 6 months of hemodialysis experience Ability and willingness to collaborate in the project
Exclusion criteria
Exclusion criteria: Underlying diseases including stage 3-4 heart failure, acute liver and thyroid disease, malignancy Regular use of pomegranate supplements or juice in the past 3 months Smoking, alcohol and hookah use Use of steroidal and non-steroidal anti-inflammatory drugs Severe reaction to syrups and placebo Pregnancy during the study period Hospitalization due to disease activation during the intervention Patient withdrawal to cooperate in the study Use of other anti-inflammatory and antioxidant supplements
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum Intercelular adehesion molecule (sICAM). Timepoint: At the beginning of the study and 10 weeks after supplement consumption. Method of measurement: Blood sample and ELISA kit. | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum Vasculae cell adhesion molecule (sVCAM 1). Timepoint: At the beginning of the study and 10 weeks after supplement consumption. Method of measurement: Blood sample and ELISA kit.;E-Selectin. Timepoint: At the beginning of the study and 10 weeks after supplement consumption. Method of measurement: Blood sample and ELISA kit.;Hs-CRP. Timepoint: At the beginning of the study and 10 weeks after supplement consumption. Method of measurement: Blood sample and ELISA kit.;MDA. Timepoint: At the beginning of the study and 10 weeks after supplement consumption. Method of measurement: Blood sample and ELISA kit. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAlireza rahmani
Iran University of Medical Sciences
Outcome results
None listed