Irritable bowel syndrome. Irritable bowel syndrome
Conditions
Interventions
Intervention 1: Intervention group: Vitamin B2 with a dose of 50 mg produced by Hakiman Teb once a day for 8 weeks. Intervention 2: Control group: The placebo contains starch and Avicel and looks simi
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Age 18 to 65 years Patients with irritable bowel syndrome according to the gastroenterologist diagnosis based on ROME-IV criteria (Recurrent abdominal pain on average at least 1 day/week in the last 3 months, associated with two or more of the following criteria: 1.Related to defecation 2.Associated with a change in frequency of stool 3.Associated with a change in form (appearance) of stool, and absence of pathological findings in digestive examinations Dairy consumption less than two units per day Having a score greater than 3 in the Hospital Anxiety and Depression Scale (HADS) questionnaire
Exclusion criteria
Exclusion criteria: Any organic intestinal disease (diagnosis based on colonoscopy in the last 5 years) and intestinal infection (diagnosis based on stool culture in suspected samples) Medical history of chronic gastrointestinal and colorectal disease Any major bowel surgery Suffering from uncontrolled systemic diseases and diabetes Regular use of laxatives or anti-diarrheal drugs or digestive motility modifiers such as Metoclopramide, Cisapride, narcotics, Diphenoxylate, etc Taking drugs that increase bleeding from the intestinal mucosa, such as Aspirin, Warfarin, Heparin, etc Pregnancy or breastfeeding, being an athlete or being hospitalized Alcohol consumption Taking any type of nutritional supplement regularly (more than 2 times a week)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mental health (depression and anxiety). Timepoint: Before intervention and after 8 weeks of intervention. Method of measurement: Hospital Anxiety and Depression Scale.;Severity of clinical outcomes. Timepoint: Before intervention and after 8 weeks of intervention. Method of measurement: Irritable bowel syndrome Symptom Severity Scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of life. Timepoint: Before intervention and after 8 weeks of intervention. Method of measurement: Irritable bowel syndrome quality of life questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactGhazaleh Mahdavi Mazdeh
Iran University of Medical Sciences
Outcome results
None listed