schizophrenia. Schizophrenia
Conditions
Interventions
Intervention 1: Intervention group: 2 capsules of 500mg Lactocare daily for 8weeks. Intervention 2: Control group: Take 2 placebo capsules daily for 8 weeks.
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Willingness to collaborate Complete the informed consent form by the patient and the patient's guardian Age range 18-65 years Schizophrenia according to DSM-V criteria (By a psychiatrist) Patients with PANSS total score = 50 Outpatient Duration of illness less than 6 years BMI = 23
Exclusion criteria
Exclusion criteria: Pregnancy and lactation A history of drug or alcohol dependence or abuse Diagnosis of mental retardation Diagnosis of major gastrointestinal, renal, heart, cancer, HIV infection ,neurological disease or other immunodeficiency problems Having suicidal or homicidal thoughts Sensitivity to probiotics, prebiotic and synbiotic Change the Dose and type of medication used during the last 2 months Receive of Antibiotics in the last month Consumption of probiotics, prebiotic or synbiotic over the last month Consumption of dietary supplements in the last month
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Symptoms of schizophrenia. Timepoint: at baseline, and after 2 month. Method of measurement: PANSS scale.;Brain-derived neurotrophic factor. Timepoint: at baseline, and after 2 month. Method of measurement: Eliza. | — |
Secondary
| Measure | Time frame |
|---|---|
| Anxiety and Depression Function. Timepoint: at baseline, and after 2 month. Method of measurement: Hospital Anxiety and Depression Scale.;Gastrointestinal symptoms. Timepoint: at baseline, and after 2 month. Method of measurement: GSRS Scale.;Physical activity. Timepoint: beginning and end of intervention. Method of measurement: IPAQ questionnaire.;Energy intake. Timepoint: beginning and end of intervention. Method of measurement: 24-hour food recall questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSomayeh Jamali paghaleh
Iran University of Medical Sciences
Outcome results
None listed