schizophrenia. Schizophrenia
Conditions
Interventions
Intervention 1: Intervention group: 2 capsules of 500mg Lactocare daily for 8weeks. Intervention 2: Control group: Take 2 placebo capsules daily for 8 weeks.
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Willingness to collaborate Complete the informed consent form by the patient and the patient's guardian Age range 18-65 years Schizophrenia according to DSM-V criteria (By a psychiatrist) Outpatient Duration of illness more than one year BMI = 23
Exclusion criteria
Exclusion criteria: Pregnancy and lactation A history of drug or alcohol dependence or abuse Diagnosis of mental retardation Diagnosis of neurological disease or any serious illness that needs treatment Diagnosis of major gastrointestinal, renal, heart, cancer, HIV infection or other immunodeficiency problems Having a history of traumatic brain injury, seizures, epilepsy, Loss of consciousness (LOC) for more than 30 minutes, or other known neurological or organic diseases of the central nervous system Having suicidal or homicidal thoughts or any safety concern by research staff Sensitivity to probiotics, prebiotic and synbiotic Subjects who may require imminent hospitalization Change the Dose and type of medication used during the last 2 months Receive of electricity shock treatment, immunosuppressive medications, stimulants, mood stabilizer during the last 3 months Receive of Antibiotics in the last month Consumption of Food or supplements containing probiotics, prebiotic and synbiotic over the last month such as kefir-yogurt-cheese and ... Consumption of dietary supplements in the last month Any disease or condition in which the researcher does not consider the participants appropriate for the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Waist circumference. Timepoint: 8 weeks. Method of measurement: Tape measure.;Fasting blood sugar. Timepoint: 8 weeks. Method of measurement: Enzymatic colorimetric.;Total cholesterol. Timepoint: 8 weeks. Method of measurement: Enzymatic colorimetric.;HDL. Timepoint: 8 weeks. Method of measurement: Enzymatic colorimetric.;TG. Timepoint: 8 weeks. Method of measurement: Enzymatic colorimetric.;Blood pressure. Timepoint: 8 weeks. Method of measurement: Mercury barometer. | — |
Secondary
| Measure | Time frame |
|---|---|
| LDL. Timepoint: 8 weeks. Method of measurement: Enzymatic colorimetric.;Serum insulin. Timepoint: 8 weeks. Method of measurement: Eliza.;HOMA-IR. Timepoint: 8 weeks. Method of measurement: Calculation by formula.;QUICKI. Timepoint: 8 weeks. Method of measurement: Calculation by formula.;HbA1c. Timepoint: 8 weeks. Method of measurement: analyzer.;Hs-CRP. Timepoint: 8 weeks. Method of measurement: Eliza.;Weight. Timepoint: 8 weeks. Method of measurement: Standard scales.;BMI. Timepoint: 8 weeks. Method of measurement: Calculation measured by height and weight. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactPoorya Basafaroodi
Iran University of Medical Sciences
Outcome results
None listed