Frailty syndrome. Age-related physical debility
Conditions
Interventions
Intervention 1: Intervention group 1: Daily intake of 20 gr isowhey and omega-3 placebo for 12 weeks. Intervention 2: Intervention group 2: Daily intake of 20 gr isowhey and two omega-3 fatty acids c
Sponsors
Iran University of Medical Sciences
University of social welfare and rehabilitation sciences
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: Community dwelling older adults Man or woman aged 60 years or older Meet one or two CHS frailty criteria: 1 - Weight loss 2 - Weakness 3 - Exhaustion 4 - Slowness of movement 5 - Low physical activity
Exclusion criteria
Exclusion criteria: Taking any steroids Taking anticoagulant drugs Regular consumption of omega-3 fatty acid supplements over the 3 months prior to study (more than twice a week) Critical illnesses including kidney failure, liver, heart disease, or chronic pulmonary failure, diabetes, malignancy (over the past 5 years) A history of exercises during the past two years (more than twice a week) Regular use of food supplements (more than twice a week) other than calcium and vitamin B12 Smoking and alcohol consumption Use of mobility devices (wheelchairs, cane ...) severe cognitive problems
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Muscle strength (Handgrip Strength):Muscle strength will assess by handgrip Strength,The difference in the rate of these outcomes changes between the intervention and placebo groups will be determined. Timepoint: At the beginning, and at the end of weeks 6 and 12 hand grip strength will be implemented. Method of measurement: Muscle strength will assess by hand grip Strength. Measured using a dynamometer device. | — |
Secondary
| Measure | Time frame |
|---|---|
| Physical performance: The difference in the rate of change between the intervention and placebo groups will be determined. Timepoint: At the beginning, and at the end of weeks 6 and 12 hand grip strength will be implemented. Method of measurement: It will be run using a clinical test (TUG; Time Up and GO) and will be performed by evaluator.;Gait Speed: The difference in the rate of change between interventional and placebo groups will be determined. Timepoint: At the beginning, and at the end of weeks 6 and 12 hand grip strength will be implemented. Method of measurement: It will be run using a clinical test and will be performed by evaluator.;Cognitive status : In order to assess the cognitive status of elderly people participating in the intervention, they will be evaluated. The difference in the rate of these outcomes changes between the intervention and placebo groups will be determined. Timepoint: Participants in the study will be evaluated at the beginning and end of the intervention(at the end of 12 week intervention). Method of measurement: Cognitive function will assess by cognitive examination. Stroop ?DSB(Digit Span Backward).;CRP(C-Reactive Protein). Timepoint: Participants in the study will be evaluated at the beginning and end of the intervention(at the end of 12 week intervention). Method of measurement: Turbidimetric test.;BDNF(Brain-derived neurotrophic factor). Timepoint: Participants in the study will be evaluated at the beginning and end of the intervention(at the end of 12 week intervention). Method of measurement: ELISA.;Mini Nutritional Assessment (MNA): assessment of the nutritional status is conducted with a brief nutritional assessment. The difference in the rate of change between the intervention and placebo groups will be determined. Timepoint: Participants in the study will be evaluated at the beginning and end of the intervention(at the end of 12 week intervention). Method of measurement: Nutritional status will assess with MNA(mini nut | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Shima Jazayeri
Iran University of Medical Sciences
Outcome results
None listed