Major Depressive Disorder. Major depressive disorder, single episode, severe with psychotic features
Conditions
Interventions
Intervention 1: Control group: placebo. Intervention 2: Intervention group: hesperidin.
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Willing to participate Clinical diagnosis of major depressive disorder; A score =15 in the 17-item Hamilton Depression Rating Scale Age 18 – 65 years;Good health status based on medical history No dietary supplement use during the previous two months Not use any drugs and antidepressant Absence of benign hormone-sensitive tumors in the ovary, uterus, breast, prostate Not having thoughts about death and suicide Not having any mental illness except anxiety Do not eat citrus more than two units per day Having physical health based on history No regular use of any supplements more than twice a week, two months before the study
Exclusion criteria
Exclusion criteria: Pregnancy and lactation patient's dissatisfaction to continue cooperation Earning each non-entry criteria
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Physical activity. Timepoint: beginning and end of intervention. Method of measurement: IPAQ questionnaire.;Energy intake. Timepoint: beginning and end of intervention. Method of measurement: Three-day food record. | — |
Primary
| Measure | Time frame |
|---|---|
| Severity of depression. Timepoint: First, middle and end of intervention. Method of measurement: Hamilton Depression Scale.;Serum level of F2 Isoprostane. Timepoint: beginning and end of intervention. Method of measurement: ELIZA.;Serum level of GDNF. Timepoint: beginning and end of intervention. Method of measurement: ELIZA.;Serum level of hs-CRP. Timepoint: beginning and end of intervention. Method of measurement: ELIZA.;Cognitive function. Timepoint: beginning and end of intervention. Method of measurement: D-KEFS questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactRoya Yazdani
Iran University of Medical Sciences
Outcome results
None listed