Major Depressive Disorder. Major depressive disorder, single episode, severe with psychotic features
Conditions
Interventions
Intervention 1: Control group: placebo 500mg daily for 8 week. Intervention 2: Intervention group: hesperidin 500mg daily foe 8 week.
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Willing to participate Clinical diagnosis of major depressive disorder; A score =15 in the 17-item Hamilton Depression Rating Scale; Age 18 – 65 years; Good health status based on medical history No dietary supplement use during the previous two months No antidepressant or steroid use Absence of benign hormone-sensitive tumors in the ovary, uterus, breast, prostate Not having thoughts about death and suicide Not having any mental illness except anxiety Do not eat citrus more than two units per day
Exclusion criteria
Exclusion criteria: Pregnancy and lactation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum level of cortisol. Timepoint: beginning and end of intervention. Method of measurement: ELIZA.;Serum level of homocysteine. Timepoint: beginning and end of intervention. Method of measurement: ELIZA.;Serum level of tryptophan. Timepoint: beginning and end of intervention. Method of measurement: ELIZA.;Serum level of kynurenine. Timepoint: beginning and end of intervention. Method of measurement: ELIZA. | — |
Secondary
| Measure | Time frame |
|---|---|
| Physical activity. Timepoint: beginning and end of intervention. Method of measurement: IPAQ questionnaire.;Energy intake. Timepoint: beginning and end of intervention. Method of measurement: Three-day food record. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHadis Sarlak
Iran University of Medical Sciences
Outcome results
None listed