overweight or obese middle-aged women. Overweight and obesity
Conditions
Interventions
Intervention 1: Intervention group 1: Receiving one capsule of 50,000 IU of vitamin D (Zahravi company) weekly, along with one capsule of synbiotic placebo containing maltodextrin (Zist takhmir compan
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
40 Years to 55 Years
Inclusion criteria
Inclusion criteria: Overweight and obese women aged 40-55 years Not being menopaused Body mass index higher than 25 kg/m2 Willingness to participate in the study
Exclusion criteria
Exclusion criteria: Vitamin D intake during the last 2-3 months, either orally or by injection Taking supplements of synbiotics, probiotics and prebiotics during the last 2-3 months Having chronic diseases such as diabetes, cardiovascular disease, uncontrolled blood pressure, liver and kidney disorders, etc. Supplements intake containing vitamins, minerals and omega-3 or fish oil Antibiotic intake during the last three weeks Following a special diet Using steroidal and non-steroidal anti-inflammatory drugs, anticonvulsants, anti-cholesterol drugs, antacids, diuretics and and laxatives over the past two months Using any medications that affect weight over the past two months (such as medications that affect carbohydrate, protein or fat metabolism, and medications that reduce or increase appetite or food intake).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intestinal microbiome. Timepoint: Intestinal microbiome assessment at the beginning of the study and after the intervention (end of week 8). Method of measurement: Real-Time PCR TaqMan method. | — |
Secondary
| Measure | Time frame |
|---|---|
| Muscle strength. Timepoint: At the beginning of the study and after the intervention (end of week 8). Method of measurement: handgrip strength and knee extension.;Muscle function. Timepoint: At the beginning of the study and after the intervention (end of week 8). Method of measurement: TGUG test.;Body composition. Timepoint: At the beginning of the study and after the intervention (end of week 8). Method of measurement: multi-frequency Bioelectrical Impedance Analysis (BIA) and InBody S10 analyzer. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammad reza Vafa
Iran University of Medical Sciences
Outcome results
None listed