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Melatonin in melasma

Clinical trial of the effectiveness of melatonin as an add-on treatment to the common treatment of melasma

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20090808002306N10
Enrollment
44
Registered
2024-07-11
Start date
2024-07-22
Completion date
Unknown
Last updated
2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Melasma. Chloasma

Interventions

Intervention 1: Intervention group: In addition to the standard treatment, which is a topical cream containing 2% hydroquinone, melatonin cream is given at night along with a 10 mg melatonin tablet ma

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Obtaining the intensity and melasma area index score (massi score) 10 Not using other topical treatments at least two weeks before participating in the research project No use of systemic steroids for the treatment of melasma for at least one month before participating in the research project Not using other treatment methods such as laser to treat melasma for at least 3 months before participating in the research project Consent and informed consent of the person to enter this research project

Exclusion criteria

Exclusion criteria: Patients non-compliance to the study protocol Utilization of other anti melasma treatments Patients' personal will to the exclusion from the study

Design outcomes

Primary

MeasureTime frame
Melasma score in Masi index. Timepoint: Measuring melasma recovery before treatment and 4 weeks after treatment. Method of measurement: Masi measurement index.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactShakiba Kianpour

Esfahan University of Medical Sciences

Shakibakianpour77@gmail.com+98 922 094 4035

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026