Primary knee osteoarthritis. Primary gonarthrosis
Conditions
Interventions
Intervention 1: Intervention group: Patients of this group consume one capsule containing 250 mg standardized hydro-alcoholic extract of Tanacetum Parthenium every 12 hours after meal for 2 months. In
Sponsors
Bagheiat-allah University of Medical Sciences
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: Diagnosis of knee osteoarthritis (grade 2 to 3 based on radiological criteria) Age between 40 and 80 years Ability of taking oral drugs and cooperation with treatment follow-up
Exclusion criteria
Exclusion criteria: Secondary osteoarthritis History of knee surgery or knee injection within the past 6 months Severe systemic diseases (cardiac, hepatic, renal, infectious) Coagulopathies or use of anticoagulant drugs Pregnancy, breastfeeding, or planning for pregnancy History of allergy to plants of the Asteraceae family (e.g., chicory, artichoke, daisy, sunflower)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total extent of knee osteoarthritis symptoms. Timepoint: At the start of study, and 1 and 2 months after intervention. Method of measurement: Western Ontario and McMaster Universities Osteoarthritis Arthritis Index questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Degree of patients satisfaction. Timepoint: At the start of study and 2 months after intervention. Method of measurement: Ten centimeter ruler.;Serum glutamic oxaloacetic transaminase. Timepoint: At the start and 2 months after intervention. Method of measurement: Autoanalyzer.;Serum glutamic pyruvic transaminase. Timepoint: At the start and 2 months after intervention. Method of measurement: Autoanalyzer.;Blood creatinine. Timepoint: At the start and 2 months after intervention. Method of measurement: Autoanalyzer.;Blood Urea Nitrogen. Timepoint: At the start and 2 months after intervention. Method of measurement: Autoanalyzer.;Complete Blood Count. Timepoint: At the start and 2 months after intervention. Method of measurement: Autoanalyzer.;Prothrombin Time. Timepoint: At the start and 2 months after intervention. Method of measurement: Autoanalyzer.;Partial Thromboplastin Time. Timepoint: At the start and 2 months after intervention. Method of measurement: Autoanalyzer.;Drug side effects. Timepoint: During the study. Method of measurement: Patient report and blood tests.;Extent of knee joint pain. Timepoint: At the start and 1 and 2 months after intervention. Method of measurement: Western Ontario and McMaster Universities Arthritis Index questionnaire.;Extent of knee joint stiffness. Timepoint: At the start and 1 and 2 months after intervention. Method of measurement: Western Ontario and McMaster Universities Arthritis Index questionnaire.;Extent of patient physical function. Timepoint: At the start and 1 and 2 months after intervention. Method of measurement: Western Ontario and McMaster Universities Arthritis Index questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAkram Rostamzadeh
Bagheiat-allah University of Medical Sciences
Outcome results
None listed