Opium addiction. Opioid dependence with withdrawal
Conditions
Interventions
Intervention 1: Intervention group: fifty patients use three 400 mg capsules of Sophora alopecuroides seed extract once orally every 24 hours for 8 days. Intervention 2: Control group: fifty patients
Sponsors
Iranian academic center for education culture and research
Eligibility
Sex/Gender
Male
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Iranian male outpatients who according to the DSM-V criteria are dependent on opium for at least 1 year Patients aged 18 to 70 years Patients whose opium dose has been constant for at least one month before study Patients residing in addiction treatment camp Patients who have not used opium for at least 5 hours before arrival in camp
Exclusion criteria
Exclusion criteria: Individuals who besides opium abuse other substances except for tobacco Patients who have other psychiatric diseases Individuals who have other important diseases like cardiac, renal and hepatic disease Individuals who have organic brain disease Individuals who have mental retardation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Score of clinical opiate withdrawal scale. Timepoint: Before intervention and 3 and 8 days after intervention. Method of measurement: Clinical Opiate Withdrawal Scale.;Patient global impression regarding efficacy of treatment. Timepoint: Eight days after intervention. Method of measurement: Visual analog scale (ten centimeter ruler). | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood level of aspartate aminotransferase. Timepoint: Before intervention and 8 days after intervention. Method of measurement: Spectrophotometer.;Blood level of alanine aminotransferase. Timepoint: Before intervention and 8 days after intervention. Method of measurement: Spectrophotometer.;Blood level of alkaline phosphatase. Timepoint: Before intervention and 8 days after intervention. Method of measurement: Spectrophotometer.;Blood level of total bilirubin. Timepoint: Before intervention and 8 days after intervention. Method of measurement: Spectrophotometer.;Blood level of direct bilirubin. Timepoint: Before intervention and 8 days after intervention. Method of measurement: spectrophotometer.;Blood level of indirect bilirubin. Timepoint: Before intervention and 8 days after intervention. Method of measurement: Spectrophotometer.;Prothrombin time. Timepoint: Before intervention and 8 days after intervention. Method of measurement: chronometer.;Blood level of creatinine. Timepoint: Before intervention and 8 days after intervention. Method of measurement: Spectrophotometer.;Level of blood urea nitrogen. Timepoint: Before intervention and 8 days after intervention. Method of measurement: Spectrophotometer. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Saeed Kianbakht
Iranian academic center for education culture and research
Outcome results
None listed