Effect of Nigella sativa seed oil in treatment of non-alcoholic fatty liver disease

Comparison of the effects of Nigella sativa seed oil mixed with honey and placebo on the hepatic sonography and blood biochemical parameters of non-alcoholic fatty liver disease patients

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20090804002288N13

Enrollment

120

Registered

2018-06-06

Start date

2017-04-04

Completion date

Unknown

Last updated

2018-07-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non-alcoholic fatty liver disease. Fatty (change of) liver, not elsewhere classified

Interventions

Intervention 1: Intervention group: sixty patients use 2.5 mL of Nigella sativa seed oil orally every 12 hours for 3 months. Intervention 2: Control group: sixty patients use 2.5 mL of placebo orally

Eligibility

Sex/Gender

All

Age

20 Years to 70 Years

Inclusion criteria

Inclusion criteria: Patients whose hepatic sonography shows they have fatty liver disease Age of 20 to 70 years

Exclusion criteria

Exclusion criteria: Child-Pugh score above 7 Hepatic disease other than non-alcoholic fatty liver disease Pregnant women Women planning pregnancy Lactating women

Design outcomes

Primary

Measure	Time frame
Fatty liver grade. Timepoint: Before intervention and 3 month? after intervention. Method of measurement: Liver sonography.;Blood level of ALT. Timepoint: Before intervention and 3 months after intervention. Method of measurement: Medical laboratory (kit).;Blood level of AST. Timepoint: Before intervention and 3 months after intervention. Method of measurement: Medical laboratory (kit).;Blood level of LDL-C. Timepoint: Before intervention and 3 months after intervention. Method of measurement: Medical laboratory (kit).;Blood level of triglyceride. Timepoint: Before intervention and 3 months after intervention. Method of measurement: Medical laboratory (kit).	—

Measure

Time frame

Fatty liver grade. Timepoint: Before intervention and 3 month? after intervention. Method of measurement: Liver sonography.;Blood level of ALT. Timepoint: Before intervention and 3 months after intervention. Method of measurement: Medical laboratory (kit).;Blood level of AST. Timepoint: Before intervention and 3 months after intervention. Method of measurement: Medical laboratory (kit).;Blood level of LDL-C. Timepoint: Before intervention and 3 months after intervention. Method of measurement: Medical laboratory (kit).;Blood level of triglyceride. Timepoint: Before intervention and 3 months after intervention. Method of measurement: Medical laboratory (kit).

—

Secondary

Measure	Time frame
Blood level of HDL-C. Timepoint: Before intervention and 3 month after intervention. Method of measurement: Medical laboratory (kit).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Saeed Kianbakht

Iranian academic center for education culture and research

kianbakht@imp.ac.ir+98 26 3476 4010

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026