Major depressive disorder. Major depressive disorder, recurrent severe without psychotic features
Conditions
Interventions
Intervention 1: First intervention group: intra muscular ketamine, NMDA antagonist, 0.5mg/kg dosage, 500 mg vial, rotex medica factory in Germany, 6-9 injection through 3weeks. Intervention 2: Second
Sponsors
Esfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Major depressive patients based on DSM 5 criteria candidate for electro convulsive therapy Age between 18-70 years old Informed consent form obtained
Exclusion criteria
Exclusion criteria: Drug side effects which discontinuation is necessary Patient`s disagreement to stay in study Deterioration of patient`s symptoms Not to respond after 4 intervention sessions. Drug sensitivity Severe or active hepatic renal cardiac urological disease Substance abuse Previous manic or hypo manic episode Catatonia Secondary depression due to another medical conditions History of psychosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Depression score in hamilton depression scale. Timepoint: Before intervention, 24 hours, one week, two weeks, three weeks, four weeks and eight weeks after begining the intervention. Method of measurement: Hamilton depression scale-17 items. | — |
Secondary
| Measure | Time frame |
|---|---|
| Suicidal scores in beck scale for suicidal ideation. Timepoint: Before intervention, 24 hours, one week, two weeks, three weeks, four weeks and eight weeks after begining the intervention. Method of measurement: Beck scale for sicidal ideation. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactGholamreza Kheirabadi
Esfahan University of Medical Sciences
Outcome results
None listed