Treatment-Resistant Major Depressive Disorder. Major depressive disorder, recurrent, unspecified
Conditions
Interventions
Intervention 1: Intervention group: In this group, ketamine at a dose of 0.5 mg/kg is administered subcutaneously twice weekly for six weeks, for a total of 12 injections. Intervention 2: Control grou
Sponsors
Esfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Age between 60-18 years Individuals who have DSM-V indicators for major depression without psychotic characteristics and mania or hypomania individuals who do not have an adequate response to monotherapy with antidepressants for at least two times (at least 4-6 weeks) Satisfaction with participating in the study
Exclusion criteria
Exclusion criteria: Pregnant or breastfeeding women History of substance dependence or abuse in the last 3 months Serious and unstable physical patients including liver, kidney, gastrointestinal, respiratory, cardiovascular diseases (such as ischemic heart disease), endocrine, neurological, hematological Untreated hypothyroidism or hyperthyroidism Current or past history of psychotic symptoms History of mania or hypomania, catatonia, or depression secondary to a medical condition History of hypertension History of seizure disorder Diagnosis of renal failure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Depression score (assessed using the HDRS). Timepoint: Before the intervention, at week 2, week 4, and week 6 during the intervention, and one month after the last intervention session. Method of measurement: Hamilton Depressive Rating Scale (HDRS). | — |
Secondary
| Measure | Time frame |
|---|---|
| Intervension side effects. Timepoint: Before the intervention, at week 2, week 4, and week 6 during the intervention, and one month after the last intervention session. Method of measurement: checklist evaluation. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactGholamreza Kheirabadi
Esfahan University of Medical Sciences
Outcome results
None listed