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Studying the effect of dexmedetomidine on perinatal depression in women undergoing cesarean section.

A comparative study of perinatal depression scores in the dexmedetomidine and placebo groups in women undergoing cesarean section .

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20090801002266N21
Enrollment
100
Registered
2025-09-22
Start date
2025-09-23
Completion date
Unknown
Last updated
2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Perinatal depression. Mild mental and behavioural disorders associated with the puerperium, not elsewhere classified Depression :postnatal NOS postpartum NOS

Interventions

Intervention 1: Intervention group: Dexmedetomidine group: Participants will receive 0.5 micrograms/kg of intravenous DEX during labor at an infusion rate of 0.375 ml/kg/hour and an infusion time of 2

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Age 18 years and above Elective cesarean section under spinal anesthesia Consent to participate in the study Clarity of the patient's medication history Balanced and normal blood pressure, pulse, and respiration

Exclusion criteria

Exclusion criteria: Sensitivity to a2-AR agonists (based on previous history) Low blood pressure (systolic blood pressure less than 90 mmHg or diastolic blood pressure less than 60 mmHg) Drug or alcohol abuse in the past 6 months Use of AR-a2 agonists or other AR-a2 antagonists during pregnancy

Design outcomes

Primary

MeasureTime frame
EPDS depression score. Timepoint: Before the intervention and 30 days after the intervention. Method of measurement: EPDS Depression Questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public Contactgholamreza kheirabadi

Esfahan University of Medical Sciences

kheirabadi@bsrc.mui.ac.ir+98 31 3624 7909

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026