pain tolerance time.
Conditions
Interventions
Intervention 1: Intervention group: memantine tablet administration. Start with 5 mg per day in the first week and adding 5 mg per day every week until patient tolerates or maximum dose 20 mg per day
Sponsors
Esfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Undertreatment in MMT program for at least 6 months No methadone dose modification in recent 6 months
Exclusion criteria
Exclusion criteria: Any analgesic medication use Sedative drugs use Substance use disorder Any kind of psychiatric disorders Any kind of neuropathy, Raynaud’s disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean threshold of pain in cold pressor test. Timepoint: In the beginning of study and after 5 weeks of memantine or placebo. Method of measurement: Cold peressor test; stopwatch.;Mean duration of maximum pain tolerance in Cold pressor test. Timepoint: In the beginning of the study and after 5 weeks of memantine or placebo administration. Method of measurement: Cold professor test will be performed for patients and the time of onset of pain and maximum pain tolerance will be measured with a stopwatch. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactGholam Reza Kheirabadi
Esfahan University of Medical Sciences
Outcome results
None listed