Treatment-Resistant Major Depressive Disorder. Major depressive disorder, recurrent, unspecified
Conditions
Interventions
Intervention 1: Intervention group: For patients in the first group, 2 mg/kg of ketamine as a solution in a glass of fruit juice orally 2 times a week (for 6 weeks) will be prescribed. Intervention 2:
Sponsors
Esfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Age between 60-18 years Individual who have DSM-V indicators for major depression without psychotic characteristics and mania or hypomania Individual who do not have an adequate response to monotherapy with antidepressants for at least two times (at least 4-6 weeks) No history of mania / hypomania Lack of psychotic symptoms Satisfaction with participating in the study
Exclusion criteria
Exclusion criteria: History of drug dependence or abuse in the last 3 months Pregnant or lactating women Serious and unstable physical patients including liver, kidney, gastrointestinal, respiratory, cardiovascular diseases (such as ischemic heart disease), endocrine, neurological, hematological. Taking medications that are contraindicated with ketamine is prohibited Untreated hypothyroidism or hyperthyroidism
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Depression score. Timepoint: The second week, the fourth week and the sixth week during the intervention and one week, one month and two months after the intervention. Method of measurement: Hamilton Depressive Rating Scale (HDRS) and Beck-2 Depression Questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Ketamin Side effects. Timepoint: The second week, the fourth week and the sixth week during the intervention and one week, one month and two months after the intervention. Method of measurement: checklist evaluation. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactGholamreza Kheirabadi
Esfahan University of Medical Sciences
Outcome results
None listed