Rapid tranquilizing of aggression by typical anti psychotics

Comparison of Haloperidol, Promethazine, Triflupeazine and Chlorpromazine in terms of velocity and durability of the sedation among acute aggressive patients

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20090726002232N4

Enrollment

Registered

2019-01-16

Start date

2017-12-22

Completion date

Unknown

Last updated

2019-01-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

aggression.

Interventions

Intervention 1: Intervention group1: promethazine 50mg (Alborz darou , Qazvin, Iran) will be injected for the first group of patients by the experienced nurses muscularly. All patients will be examine

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Satisfaction to enter the study by patient's companion or protector Being at the age of 18 to 60 years old Having verbal aggression Having physical aggression No contraindication to any of the medications

Exclusion criteria

Exclusion criteria: Failure to cooperate with the family to complete the intervention The presence of any NMS related symptoms

Design outcomes

Primary

Measure	Time frame
Verbal Aggression. Timepoint: At the beginning of the study and within two hours after a sedative injection. Method of measurement: Clinical Observation.;Physical Aggression. Timepoint: At the beginning of the study and within two hours after a sedative injection. Method of measurement: Clinical Observation.;The velocity of the onset effect of sedative injections. Timepoint: Within two hours after a sedative injection. Method of measurement: Stopwatch.;Duration of the effect of sedative injections. Timepoint: Within two hours after a sedative injection. Method of measurement: Stopwatch.	—

Measure

Time frame

Verbal Aggression. Timepoint: At the beginning of the study and within two hours after a sedative injection. Method of measurement: Clinical Observation.;Physical Aggression. Timepoint: At the beginning of the study and within two hours after a sedative injection. Method of measurement: Clinical Observation.;The velocity of the onset effect of sedative injections. Timepoint: Within two hours after a sedative injection. Method of measurement: Stopwatch.;Duration of the effect of sedative injections. Timepoint: Within two hours after a sedative injection. Method of measurement: Stopwatch.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSeyed Ghafur Mousavi

Esfahan University of Medical Sciences

mousavi@med.mui.ac.ir+98 31 3222 2127

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026