Obesity. Obesity due to excess calories
Conditions
Interventions
Intervention 1: Intervention group: Patients in this group will receive dietary recommendations and boron citrate capsules including 10 mg boron for 12 weeks. Boron citrate capsules is made in Iran,
Sponsors
Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Ages between 18 to 60 years body mass index (BMI) 30 to 40 kg/m2 Residence in Tabriz
Exclusion criteria
Exclusion criteria: Smokers Consuming alcohol Individuals taking chemical or herbal drugs for weight loss, hepatotoxic drugs, anti-hypertensive drugs, lipid-lowering and anti-diabetic drugs, corticosteroid, and non-steroidal anti-inflammatory drugs and antibiotics. Individuals who are pregnant, lactating, menopause, and those who use birth control pills and estrogen Individuals who have some pathologic conditions such as cardiovascular, liver, thyroid, parathyroid, kidney, gastrointestinal tract and autoimmune diseases as well as suffering from polycystic ovary syndrome, cancer and inflammatory disease Individuals who underwent weight loss surgery in the last year or weight loss diets in the last three months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PPAR-? gene expression. Timepoint: The beginning and end of the study. Method of measurement: Measurement of gene expression by RT-PCR method.;SIRT1 gene expression. Timepoint: The beginning and end of the study. Method of measurement: Measurement of gene expression by RT-PCR method.;PGC-1a gene expression. Timepoint: The beginning and end of the study. Method of measurement: Measurement of gene expression by RT-PCR method.;AMPK gene expression. Timepoint: The beginning and end of the study. Method of measurement: Measurement of gene expression by RT-PCR method. | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum level of thyroid Stimulating hormone (TSH). Timepoint: The beginning and end of the study. Method of measurement: ELISA.;Serum level of triiodothyronine (T3). Timepoint: The beginning and end of the study. Method of measurement: ELISA.;Serum level of tetraiodothyronine (T4). Timepoint: The beginning and end of the study. Method of measurement: ELISA. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Alireza Ostadrahimi
Tabriz University of Medical Sciences
Outcome results
None listed