kidney stone. Calculus of kidney and ureter
Conditions
Interventions
Intervention 1: intervention group: n= 80. Patients in this group will receive 2 capsules of sodium pentaborate (NaB) supplements for 8 weeks daily . each capsules contain 5 mg sodium pentaborate (Na
Sponsors
Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 50 Years
Inclusion criteria
Inclusion criteria: Men and women aged 20-50 years Patients with kidney stones with urologist diagnosis (other than obstructive, infectious, and ureter stones) Patients with kidney stones who, can be follow with drug therapy for a maximum of 3 month,according to a urologist diagnosis Not suffering from liver and kidney failure Patients who are willing to participate in the study
Exclusion criteria
Exclusion criteria: Pregnancy or lactation Suffering from other kidney related metabolic disorders and disease, at the same time Smoking Having a special diet Patients with obstructive stones, infections, and ureter stones and Emergency cases requiring special treatment or surgery with the diagnosis of urologists Changes in the drug protocol during the study
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Values of liver functional tests (ALT_AST_ALP). Timepoint: Before and after treatment. Method of measurement: Enzymatic methods.;Urine culture status. Timepoint: Before and after treatment. Method of measurement: Standard methods.;Dietary status (Dietary intake and Appetite). Timepoint: Before and after treatment. Method of measurement: FFQ and VAS questionnaires.;Serum levels of oxidative Stress indices (Malondialdehyde (MDA) and Total antioxidant capacity). Timepoint: Before and after treatment. Method of measurement: Spectrophotometry.;Status of some blood indices [PT(prothrombin time), ESR (erythrocyte sedimentation rate), INR (International Normalized Ratio), Albumin]. Timepoint: Before and after treatment. Method of measurement: Standard method, Westergren, Calculate, ELISA kit. | — |
Primary
| Measure | Time frame |
|---|---|
| Calculi status. Timepoint: Weeks 0, 4 and 8 study. Method of measurement: Ultra sonography.;Values of kidney functional tests (Urea, Creatinin, BUN, Uric acid, Analysis of urinary ions (Ca, k, Na), Serum PTH). Timepoint: Before and after treatment. Method of measurement: Enzymatic methods, Atomic absorption, ELISA kit.;Status of metabolic syndrome. Timepoint: Before and after treatment. Method of measurement: Measurement of blood pressure with stethoscope, Measurement of waist circumference , Measurement of HDL-cholesterol, triglyceride, FBS and fasting Insulin through enzymatic methods. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMaryam Behrooz
Tabriz University of Medical Sciences
Outcome results
None listed