Diabetes mellitus Type 2. Diabetes
Conditions
Interventions
Intervention 1: Group 1 will receive sodium butyrate capsules (BodyBio) for 6 weeks at a daily dose of 600 mg in the form of capsules of 100 mg with meals. Intervention 2: Control group: Group 2 will
Sponsors
Nutrition Research Center, Tabriz University of Medical Science
Eligibility
Sex/Gender
All
Age
30 Years to 50 Years
Inclusion criteria
Inclusion criteria: Willingness to participate in the study Ages between 30 to 50 years (both sexes) Diagnosis of type 2 diabetes Body mass index (BMI) between 27 to 35 kg/m2 People who control their diabetes just by using blood glucose lowering tablets.
Exclusion criteria
Exclusion criteria: Unwillingness to participate in the study Chronic diseases such as cardiovascular disorders and ... Kidney, liver and thyroid disorders Rheumatic Diseases Inflammatory diseases of the gastrointestinal tract or malabsorption, such as sprue and crowns Insulin injection, taking estrogenic drugs, progesterone & corticosteroids Taking vitamin supplements; minerals; omega-3 and antibiotics for three weeks before the study Changes in diet and physical activity Smoking Having certain physiological conditions like pregnancy and lactation and menopause
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| TLR-4 expression. Timepoint: Before & after the intervention. Method of measurement: Real-time PCR.;NLRP3 expression. Timepoint: Before & after the intervention. Method of measurement: Real-time PCR.;Caspase-1 expression. Timepoint: Before & after the intervention. Method of measurement: Real-time PCR.;ASC expression. Timepoint: Before & after the intervention. Method of measurement: Real-time PCR.;IL-1ß expression. Timepoint: Before & after the intervention. Method of measurement: Real-time PCR.;IL-18 expression. Timepoint: Before & after the intervention. Method of measurement: Real-time PCR.;Glutathion Peroxidase (GPx). Timepoint: Before & after the intervention. Method of measurement: Kit.;Nitric Oxide (NO). Timepoint: Before & after the intervention. Method of measurement: Kit.;Fasting Blood Glucose. Timepoint: Before & after the intervention. Method of measurement: Enzymatic assay.;Fasting Insulin. Timepoint: Before & after the intervention. Method of measurement: ELISA.;HbA1c. Timepoint: Before & after the intervention. Method of measurement: Kit.;HOMA-IR. Timepoint: Before & after the intervention. Method of measurement: HOMA-IR formula: [fasting insulin (µU/ml)*fasting glucose (mg/dL)]/ 405.;Triglyceride. Timepoint: Before & after the intervention. Method of measurement: Enzymatic method.;HDL-Cholesterol. Timepoint: Before & after the intervention. Method of measurement: Enzymatic method.;Total Cholesterol. Timepoint: Before & after the intervention. Method of measurement: Enzymatic method.;LDL-Cholesterol. Timepoint: Before & after the intervention. Method of measurement: Friedewald's formula: LDL= TC - [HDL + (TG/5)]. | — |
Secondary
| Measure | Time frame |
|---|---|
| Systolic Blood Pressure. Timepoint: Before & after the intervention. Method of measurement: Digital barometer.;Diastolic Blood Pressure. Timepoint: Before & after the intervention. Method of measurement: Digital barometer.;Energy and macro-nutrient intake. Timepoint: Before & after the intervention. Method of measurement: Questionnaire (3 days dietary record).;Weight. Timepoint: Before & after the intervention. Method of measurement: scale.;Body Mass Index. Timepoint: Before & after the intervention. Method of measurement: BMI formula.;Waist circumference. Timepoint: Before & after the intervention. Method of measurement: Nonelastic flexible tape.;Hip circumferences. Timepoint: Before & after the intervention. Method of measurement: Nonelastic flexible tape.;Waist to Hip Ratio (WHR). Timepoint: Before & after the intervention. Method of measurement: Calculation. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactZeinab Khosravi
Tabriz University of Medical Sciences
Outcome results
None listed