Infertility in adenomyosis. Female infertility of uterine origin
Conditions
Interventions
Intervention 1: Control group: This group will received dipherelin (3.75 mg) On day 3 after LMP,and then repeat after28 days .7-14 days after second dose then estradiol valerate is administered at th
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
30 Years to 45 Years
Inclusion criteria
Inclusion criteria: Age 30-45 Years First or second cycle of embryo transfer Presence of adenomyosis, either focal or generalized, with or without concomitant diagnosis of endometriosis and myoma Normal uterine cavity
Exclusion criteria
Exclusion criteria: recurrent implantation failure, hydrosalpinx, uterine anomaly , sever male factor infertility myoma >5 cm sever endometriosis uterine distortion because of myoma
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical pregnancy rate. Timepoint: Observation of at least one fetus with cardiac activity at 4-6 weeks after embryo transfer in vaginal ultrasound. Method of measurement: Vaginal ultrasound.;Chemical pregnancy rate. Timepoint: 14 days after embryos transfer. Method of measurement: by using laboratory kits for blood Beta-hCG assay. | — |
Secondary
| Measure | Time frame |
|---|---|
| Live birth rate. Timepoint: The delivery of a fetus who shows evidence of life after that is entirely outside of the mother. Method of measurement: Delivery report from hospital.;Miscarriage rate. Timepoint: Before the 20th week of pregnancy. Method of measurement: Ultrasound evidence of clinical pregnancy loss before 20 weeks of gestation.;Twin pregnancy rate. Timepoint: 6 to 7 weeks after embryo transfer. Method of measurement: observation of two gestational sacs along with the fetal poles with heart beat in ultrasound examination. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public Contactdr marzieh eslami moayed
Tehran University of Medical Sciences
Outcome results
None listed