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Comparison of two endometrial preparation protocols for frozen-thawed embryo transfer in polycystic ovarian syndrome

Comparison of Hormone replacement therapy with mild ovarian stimulation as endometrial preparation protocols for frozen-thawed embryo transfer in polycystic ovarian syndrome

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20090526001952N12
Enrollment
120
Registered
2020-03-30
Start date
2018-09-23
Completion date
Unknown
Last updated
2020-04-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Polycystic ovarian syndrome. Polycystic ovarian syndrome

Interventions

Intervention 1: Intervention group 1: This group will be received estradiol valerate (Aboureihan Co.). On day 3 after LMP, estradiol valerate is administered at the dose of 4 mg and will be increased
2.5 mg, b.i.d.) on day 3 after LMP for 5 days. Afterward treatment with HMG (Karma Co.
75-150 mg, daily) on day 5 - 9 after LMP. Endometrial thickness, follicle size, and LH serum levels are measured frequently and in case of follicle size of 12-13 mm, an LH measurement will be done on
5000 - 10000 IU) administration for ovulation induction. On day 20th, if endometrial Thickness was less than 7 mm the transfer cycle will be canceled regardless of follicle condition.

Sponsors

Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 35 Years

Inclusion criteria

Inclusion criteria: Age 20- 35 Years First or second cycle of embryo transfer Normal uterine cavity

Exclusion criteria

Exclusion criteria: Severe male factor Patients with pregestational diagnosis Severe endometriosis Concomitant immunologic disease Follicle stimulating hormone more than 10 IU Body mass index equal or more than 30

Design outcomes

Primary

MeasureTime frame
Number (ratio) of successful pregnancy. Timepoint: 40 weeks after study initiation. Method of measurement: Medical examination and ultrasound.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Azadeh Hosseini

Tehran University of Medical Sciences

ahosseini11@gmail.com+98 21 7788 3283

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 25, 2026