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The effects of magnesium sulfate in controlling pain and headache in cesarean section

Investigating the effects of magnesium sulfate compared to placebo in controlling pain during the first 24 hours after cesarean delivery with spinal anesthesia in pregnant women, a double-blind study

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20090525001946N11
Enrollment
118
Registered
2024-01-02
Start date
2024-01-05
Completion date
Unknown
Last updated
2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

low and prophylactic doses magnesium sulfate on pain control. Complications of labour and delivery

Interventions

Intervention 1: Intervention group: 50 mg/kg of magnesium sulfate in 100 ml of isotonic normal saline solution produced by Pasteur Institute factory and the Iran Injection and Pharmaceutical Products

Sponsors

Rasht University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
9 Years to 45 Years

Inclusion criteria

Inclusion criteria: Cesarean section with spinal anesthesia Placement in class II of anesthesia Being nuli para Acceptable candidate for caesarean section

Exclusion criteria

Exclusion criteria: Magnesium intake 24 hours before surgery History of any surgery Suffering from kidney dysfunction Suffering from heart dysfunction Suffering from Lung dysfunction Suffering from Liver dysfunction Suffering from Myopathy dysfunction Suffering from neuropathy dysfunction Occurrence of severe preeclampsia symptoms Occurrence of eclampsia symptoms Having contraindications for spinal injection such as injection site infection Having contraindications for spinal injection such as coagulation disorders Severe obesity (BMI>30) Treatment with calcium receptor blocking drugs Drug addiction History of long-term use of steroids Allergy to magnesium Multiple pregnancy

Design outcomes

Primary

MeasureTime frame
Amount of pain in the abdominal surgery area. Timepoint: In the first 6, 12, 18, and 24 hours. Method of measurement: Pain with scores between zero and ten using a Numeric Pain Rating Scale.;Amount of headache. Timepoint: At 6, 12, 18, and 24 hours on the first day and at 12 o'clock on the second and third day after the operation. Method of measurement: Using the headache scoring scale (Visual Analog Scale) with scores between 0 and 10.;The amount of painkillers used. Timepoint: In the first 6, 12, 18, and 24 hours. Method of measurement: If the postoperative VAS, NRS score is greater than three.

Secondary

MeasureTime frame
Sensory block. Timepoint: 30 seconds before the skin incision and then from the time the skin incision is made until the end of the surgery, every five minutes until the end of the sensory block.?. Method of measurement: Using a short needle (pin prick test) for sensory block.;Motor block. Timepoint: 30 seconds before the skin incision and then from the time the skin incision is made until the end of the surgery, every five minutes until the end of the sensory block. Method of measurement: Evaluation of motor block based on three questions of modified Bromage scale.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSedighe Bab Eghbal

Rasht University of Medical Sciences

Sedigheh.eghbal@yahoo.com+98 13 3336 9224

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026