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Use of actinidin in skin grafting

Investigating the efficacy of actinidin isolated epidermis grafting in repigmentation of vitiligo patients

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20090515001906N13
Enrollment
96
Registered
2023-12-02
Start date
2022-09-23
Completion date
Unknown
Last updated
2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vitiligo. Vitiligo

Interventions

Intervention 1: Intervention group: For each patient, after local anesthesia in the donor site, the epidermis is separated with a thin layer of dermis by a dermatome. In the next step, the separated s

Sponsors

Kermanshah University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
13 Years to No maximum

Inclusion criteria

Inclusion criteria: Age 13 to 60 years The presence of at least two affected areas Persistent vitiligo vulgaris or segmental vitiligo (there has been no increase in the size of depigmented patches for at least one year) Lack of appropriate response to drug and phototherapy treatments The rate of involvement is less than 30% of the total body surface

Exclusion criteria

Exclusion criteria: Appropriate response to drug and phototherapy treatments History of cardiovascular disease Age under 13 years and over 60 years Pregnancy and breastfeeding Positive history of Kobner Phenomenon Presence of hypertrophic or keloid scars Unstable vitiligo during the past 1 year Presence of active infection at the site

Design outcomes

Primary

MeasureTime frame
The degree of repigmentation is described as poor, moderate, good and excellent. Timepoint: The beginning of the study, the second week, the second month and the sixth month. Method of measurement: Taking photos with Finepix camera and comparing photos at set times.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMarzieh Fathi

Kermanshah University of Medical Sciences

rasad313313@gmail.com+98 83 3835 9054

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026