obesity. Overweight and obesity
Conditions
Interventions
Intervention 1: Intervention group: Receive a weight loss diet and probiotic supplement for 12 weeks, A weight loss diet (500 kcal less than the daily requirement and the composition of the prescribed
Sponsors
Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 55 Years
Inclusion criteria
Inclusion criteria: Age range: 20 to 55 years Body mass index: 30 to 40 kg/m2 Interest in participating in the project
Exclusion criteria
Exclusion criteria: unwillingness to cooperate pregnancy and lactation smoking cardiovascular disease (history of myocardial infarction and use of digoxin and warfarin) renal disease (creatinine above 2 mg/dL and GFR less than 30 ) Liver disease (liver enzyme levels two and a half times normal) inflammatory bowel disease such as colitis diabetes cancer history of gastrointestinal surgery use of antibiotics during the two months before the start of the study and during the study taking multivitamin supplements during the study common use of probiotics and prebiotics during the month before the start of the study common use Anti-inflammatory drugs during the month before the start of the study use of weight loss drugs in the last 3 months history of special diet for weight loss in the last 3 months history of mental illness
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Weight. Timepoint: Beginning and end of the intervention. Method of measurement: Digital scale.;Body mass index. Timepoint: Beginning and end of the intervention. Method of measurement: Formula.;Waist circumference and hip circumference. Timepoint: Beginning and end of the intervention. Method of measurement: Tape meter. | — |
Secondary
| Measure | Time frame |
|---|---|
| Waist to hip ratio. Timepoint: Beginning and end of the intervention. Method of measurement: Formula.;Fasting glucose blood. Timepoint: Beginning and end of the intervention. Method of measurement: Autoanalyzer.;Insulin. Timepoint: Beginning and end of the intervention. Method of measurement: Eliza.;Total cholesterol. Timepoint: Beginning and end of the intervention. Method of measurement: Spectrophotometry.;HDL. Timepoint: Beginning and end of the intervention. Method of measurement: Spectrophotometry.;LDL. Timepoint: Beginning and end of the intervention. Method of measurement: Spectrophotometry.;TG. Timepoint: Beginning and end of the intervention. Method of measurement: Spectrophotometry.;Liver enzymes (ALT and AST). Timepoint: Beginning and end of the intervention. Method of measurement: Colorimetric test.;HsCRP. Timepoint: Beginning and end of the intervention. Method of measurement: Eliza.;GLP1. Timepoint: Beginning and end of the intervention. Method of measurement: Eliza.;Intestinal microbiota. Timepoint: Beginning and end of the intervention. Method of measurement: Real-time polymerase chain reaction. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHanieh-Sadat Ejtahed
Tehran University of Medical Sciences
Outcome results
None listed