Refractory seizure. Epilepsy and recurrent seizures
Conditions
Interventions
Intervention 1: Intervention group: The intervention group will be prescribed melatonin tablet at a dose of 10 mg/m2 body surface area in the form of a 3 mg tablet manufactured by Razak Pharmaceutical
Sponsors
Sari University of Medical Sciences
Eligibility
Sex/Gender
All
Age
1 Years to 21 Years
Inclusion criteria
Inclusion criteria: Age 1 to 21 years with a history of seizure Seizure is not controlled with at least 3 different anticonvulsants At least four or more seizure episodes in last month
Exclusion criteria
Exclusion criteria: Treatable seizure History of cardiovascular syndromes Neurodegenerative syndromes Hepatic and renal dysfunction History of pseudo seizure Blindness Irregular drug use Unreliable parents History of vasculitis Severe and persistent progressive seizure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Frequency and duration of seizure. Timepoint: Baseline (before intervention), first, second, third and fourth weeks. Method of measurement: Frequency and duration of seizure in day.;Sleep quality. Timepoint: Baseline (before intervention), first, second, third and fourth weeks. Method of measurement: The Pittsburgh Sleep Quality Index (PSQI). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Ali Abbaskhanian
Sari University of Medical Sciences
Outcome results
None listed