Evaluation the relationship between cognitive function and inflammatory factors in patients with MS

Evaluation of the relationship between BDNF, VEGF, proinflammatory and anti-inflammatory cytokines with cognitive function and quality of life following 6 weeks aerobic training in comparison with control group in relapsing-remitting multiple sclerosis patients.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20090203001637N5

Enrollment

Registered

2018-01-21

Start date

2017-02-19

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multiple Sclerosis. Multiple sclerosis

Interventions

Intervention 1: Control group:They will take part in pre-post evaluation process only. They have be given medicine and diet similar to intervention group. they will not do and physical training

Rehabilitation

Control group:They will take part in pre-post evaluation process only. They have be given medicine and diet similar to intervention group. they will not do and physical training in study perio

Intervention group :6 weeks endurance exercise with stationary bike with 70% maximal heart rate, 3 days in week.

Eligibility

Sex/Gender

All

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Male and female patients by physicians specializing in neurology examination and diagnosis- relapsing remitting MS Be laid. Age between 18 to 40 years Having Disability 2-5 as base,Expanded Disability Status Scale ( EDSS ) .

Exclusion criteria

Exclusion criteria: participating in sports activities in a serious and regular manner at least a year before participating in the study. Having history of cardiovascular disease and blood pressure. Use of steroids drugs. Use of antidepressants drugs. Use of neuroleptics drugs. Use of immunosuppressive drugs. Having history of infectious illness. Having history of metabolic illness. Having history of i mental and cognetive illness. Participants have no desire to continue

Design outcomes

Primary

Measure	Time frame
Blood levels of BDNF. Timepoint: Before and after the intervention. Method of measurement: Eenzyme -linked immunosorbent assay kits.;Blood levels ofl VEGF. Timepoint: Before and after the intervention. Method of measurement: Eenzyme -linked immunosorbent assay kits.;Blood levels of IL6. Timepoint: Before and after the intervention. Method of measurement: Eenzyme -linked immunosorbent assay kits.;Blood levels of IL10. Timepoint: Before and after the intervention. Method of measurement: Eenzyme -linked immunosorbent assay kits.;Brain Cognitive function. Timepoint: Before and after the intervention. Method of measurement: Cognitive Testing Software.	—

Measure

Time frame

Blood levels of BDNF. Timepoint: Before and after the intervention. Method of measurement: Eenzyme -linked immunosorbent assay kits.;Blood levels ofl VEGF. Timepoint: Before and after the intervention. Method of measurement: Eenzyme -linked immunosorbent assay kits.;Blood levels of IL6. Timepoint: Before and after the intervention. Method of measurement: Eenzyme -linked immunosorbent assay kits.;Blood levels of IL10. Timepoint: Before and after the intervention. Method of measurement: Eenzyme -linked immunosorbent assay kits.;Brain Cognitive function. Timepoint: Before and after the intervention. Method of measurement: Cognitive Testing Software.

—

Secondary

Measure	Time frame
Quality of life. Timepoint: Before and after the intervention. Method of measurement: Questionare SF 36.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSedighe Kahrizi

Tarbiat Modares University (T.M.U)

kahrizis@modares.ac.ir+98 21 8288 4511

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026