The effect of combination of dexmedetomidine-bupivacaine with ketamine-bupivacaine on post poerative pain after lower abdominal surgeries

The effect of preemptive subcutaneous infiltration of dexmedetomidine-bupivacaine combination with ketamine-bupivacaine combination on pain after lower abdominal surgeries

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20090129001615N9

Enrollment

Registered

2023-12-02

Start date

2023-09-22

Completion date

Unknown

Last updated

2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

anesthesia.

Interventions

Intervention 1: Intervention group 1: recipient of 40 cc bupivacaine 0.25% (made by Exir institutein) combination with dexmedetomidine 1.5 µg/kg (made by Imozhen institute) before surgical incision. I

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: atients who are candidates for elective lower abdominal surgery Age range 18-65 years ASA 1 or 2

Exclusion criteria

Exclusion criteria: Patients with a history of allergy to the studied drugs (dexmedetomidine, ropivacaine, and ketamine) Patients with a history of drug addiction Patients with mental health problems Obese patients weighing more than 100 kg Patients with inability to express pain intensity based on VAS criteria Infection at the surgical incision site Any change in anesthesia method

Design outcomes

Primary

Measure	Time frame
Post operatie pane. Timepoint: Every 15 minutes during recovery and at 2, 6, 12 and 24 hours after the operation. Method of measurement: With using vigual analog scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli Mehrabi Koushki

Esfahan University of Medical Sciences

al.mehrabi@gmail.com+98 31 3668 2974

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026