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Investigating the preemptive effect of two different doses of dexmedetomidine on changes in blood pressure and heart rate following the use of a tourniquet during a randomized trial of upper extremity orthopedic surgery

Investigating the preemptive effect of two different doses of dexmedetomidine on changes in blood pressure and heart rate following the use of a tourniquet during a randomized trial of upper extremity orthopedic surgery

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20090129001615N7
Enrollment
90
Registered
2023-05-13
Start date
2023-05-21
Completion date
Unknown
Last updated
2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Blood pressure. Condition 2: Heart rate.

Interventions

Intervention 1: Intervention group one: In the dexmedetomidine 1 group, 1 (kg/µg) dexmedetomidine is infused within 10 minutes and then continued with a dose of 0.75 (kg/µg) dexmedetomidine infusion d

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients with ASA (American Society of Anesthesiologists) = 1, aged 18-65 years, who are Patients aged 18-65 years Candidates for upper limb orthopedic surgery under tourniquet who undergo general anesthesia

Exclusion criteria

Exclusion criteria: Addicted people People with a history of allergy to the studied drugs People with heart, liver or kidney failure People with ASA = 2

Design outcomes

Primary

MeasureTime frame
Blood pressure. Timepoint: At baseline times (before administration of study drugs) and then at times 0, 10, 20, 30, 40, 50 and 60 minutes after tourniquet inflation and then immediately after deflation. Method of measurement: Sphygmomanometer.;Heart rate. Timepoint: At baseline times (before administration of study drugs) and then at times 0, 10, 20, 30, 40, 50 and 60 minutes after tourniquet inflation and then immediately after deflation. Method of measurement: Electrocardiogram.;Oxygen saturation. Timepoint: At baseline times (before administration of study drugs) and then at times 0, 10, 20, 30, 40, 50 and 60 minutes after tourniquet inflation and then immediately after deflation. Method of measurement: Pulse oximeter.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAzim Honarmand

Esfahan University of Medical Sciences

honarmand@med.mui.ac.ir+98 913 110 2327

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026