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Comparison of the effect of two drug combinations: Etomidate-Sufentanil with Ketamine-Sufentanil-Midazolam during laryngoscopy

Comparison of the effect of two drug combinations: Etomidate-Sufentanil with Ketamine-Sufentanil-Midazolam on changes in heart rate and blood pressure after laryngoscopy and endotracheal intubation

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20090129001615N4
Enrollment
96
Registered
2020-10-28
Start date
2020-09-22
Completion date
Unknown
Last updated
2020-11-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

patients who need general anesthesia with tracheal intubation.

Interventions

Intervention 1: Intervention group 1: Patients will receive Etomidate (10 cc ampoules, 2 milligrams per cc, made by Abu Reihan Pharmaceutical Company) in the amount of 0.3 milligrams per kilogram body

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients with ASA (American Society of Anesthesiologists) grade:1 or 2 Patients aged 18 to 65 years Patients who need tracheal intubation and general anesthesia

Exclusion criteria

Exclusion criteria: Patients with heart failure disease Patients who are addicted to drugs Patients with airway anomalies Patients with hepatic failure disease Patients with renal failure disease Patients with over 65 years or under 18 years

Design outcomes

Primary

MeasureTime frame
Systolic blood pressure mean in each group. Timepoint: Before intervention and 1, 3, 5 and 10 minutes after laryngoscopy. Method of measurement: Blood pressure manometer.;Diastolic blood pressure mean in each group. Timepoint: Before intervention and 1, 3, 5 and 10 minutes after laryngoscopy. Method of measurement: Blood pressure manometer.;Heart rate mean in each group. Timepoint: Before intervention and 1, 3, 5 and 10 minutes after laryngoscopy. Method of measurement: Heart monitoring device.

Secondary

MeasureTime frame
Arterial oxygen saturation mean in each group. Timepoint: Before intervention and 1, 3, 5 and 10 minutes after laryngoscopy. Method of measurement: Pulse oximeter.;Electrocardiogram ST-T changes relative frequency in each group. Timepoint: Before intervention and 1, 3, 5 and 10 minutes after laryngoscopy. Method of measurement: Electrocardiogram.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAzim Honarmand

Esfahan University of Medical Sciences

honarmand@med.mui.ac.ir+98 31 3792 8008

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026