Evaluation and Comparison of the effect of Intracuff Alkalinized Lidocaine versus Intravenous Lidocaine on Coughing and Sore throat after Surgical Operation

Evaluation and Comparison of Intracuff Alkalinized Lidocaine versus Intravenous Lidocaine effects on Coughing and Postoperative Sore throat

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20090129001615N3

Enrollment

Registered

2019-11-04

Start date

2017-10-01

Completion date

Unknown

Last updated

2019-12-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Coughing after intubation. Condition 2: Sore throat after intubation. Cough Pain in throat

Interventions

Intervention 1: Intervention group: Intracuff Lidocaine Group, The population of the first group was 33. Initially, in this group, the cuff of endotracheal tube was slowly filled with air until no sou

then at the end of the surgery and after extubation 1.5 mg/kg lidocaine was injected intravenously. Intervention 3: Control group: the cuff of endotracheal tube was filled only with air to the pressur

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients with ASA I or ASA II Patients aged 18 to 65 years Patients who were candidates for Elective Surgery under General Anesthesia requiring Tracheal Intubation

Exclusion criteria

Exclusion criteria: Patients with Underlying Conditions including Uncontrolled Diabetes, Uncontrolled Hypertension, Asthma Patients with Hyper-Reactive Airway Disease Patients with history of Lidocaine Susceptibility Patients with Chronic Cough and Sore Throat

Design outcomes

Primary

Measure	Time frame
Postoperative Cough frequency. Timepoint: immediately after extubation, within fifteen minutes, one, two, three, twelve and twenty-four hours after extubation. Method of measurement: Counting Cough Frequency.;Postoperative Sorethroat. Timepoint: immediately after extubation, within fifteen minutes, one, two, three, twelve and twenty-four hours after extubation. Method of measurement: Visual Analogue Scale.	—

Measure

Time frame

Postoperative Cough frequency. Timepoint: immediately after extubation, within fifteen minutes, one, two, three, twelve and twenty-four hours after extubation. Method of measurement: Counting Cough Frequency.;Postoperative Sorethroat. Timepoint: immediately after extubation, within fifteen minutes, one, two, three, twelve and twenty-four hours after extubation. Method of measurement: Visual Analogue Scale.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAzim Honarmand

Esfahan University of Medical Sciences

honarmand@med.mui.ac.ir+98 31 3668 0048

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026