Schizophrenia. Schizophrenia
Conditions
Interventions
Intervention 1: Control group: treated with risperidone 2 mg three times a day + placebo for 8 weeks. Intervention 2: Intervention group: treated with risperidone 2 mg three times a day + Rosiglitazo
Sponsors
University of social welfare and rehabilitation sciences
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Diagnosis of schizophrenia based on DSM-5 Age between 18-50 At least 2 years have been passed since the diagnosis Have been stable with risperidone treatment for at least 2 months Normal ECG
Exclusion criteria
Exclusion criteria: Head trauma History of shock therapy during the last three months Neurosurgery Diagnosis of acute or chronic systemic disease Alcohol or drug addiction in the last 6 months Suicidal ideation Pregnancy or lactation IQ less than 70 based on the diagnosis of a psychiatrist ECT during recent two months Taking oral antipsychotics, excluding risperidone, in the past week or long-acting antipsychotics in the past month The presence of another diagnosis in axis II History of heart disease Family history of heart disease and heart failure Taking insulin Liver disorders The development of a drug complication that requires emergency action: edema, congestive heart failure, heart pain and changes in the basic ECG, hypoglycemia, the occurrence of malignant neuroleptic syndrome
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of schizophrenia. Timepoint: Baseline and weeks 4 and 8. Method of measurement: By Positive and Negative Syndrome Scale (PANSS). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Shahin Akhondzadeh
Tehran University of Medical Sciences
Outcome results
None listed