Dextromethorphan and Fluoxetine for the treatment of OCD

Dextromethorphan combination therapy with Fluoxetine in the treatment of moderate to severe OCD : A randomized, double-blind, placebo-controlled trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20090117001556N158

Enrollment

Registered

2024-04-10

Start date

2024-05-21

Completion date

Unknown

Last updated

2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obsessive-compulsive disorder. Obsessive-compulsive disorder

Interventions

Intervention 1: Control group: Patients are initially treated with fluoxetine 20 mg daily, increasing to 60 mg daily from week 6 and continuing for 4 weeks, plus placebo, three times daily for 10 week

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Age between 18 to 60 years old Diagnosis of OCD based on DSM-5 Score of >21 in Yale–Brown obsessive-compulsive scale (Y-BOCS)

Exclusion criteria

Exclusion criteria: Receiving any treatment up to 6 weeks before the start of the trial Diagnosis of another psychiatric disorder

Design outcomes

Primary

Measure	Time frame
Severity of OCD symptoms. Timepoint: Baseline and weeks 5 and 10. Method of measurement: By Yale–Brown obsessive-compulsive scale (Y-BOCS).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Shahin Akhondzadeh

Tehran University of Medical Sciences

s.akhond@sina.tums.ac.ir+98 21 5541 2222

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026