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The effect of Saffron on motor and depressive symptoms in patients with Parkinson's disease

Evaluating the efficacy and safety of Saffron add-on treatment in the improvement of motor and depressive symptoms in patients with Parkinson's disease: A randomized, double-blind, placebo-controlled clinical trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20090117001556N145
Enrollment
50
Registered
2022-08-15
Start date
2022-10-23
Completion date
Unknown
Last updated
2022-08-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Severity of depressive and motor symptoms. Parkinson's disease

Interventions

Intervention 1: Control group: routine Parkinson's disease drug with the dose specified by the doctor + placebo capsule twice a day. Intervention 2: Intervention group: routine Parkinson's disease dru

Sponsors

Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
30 Years to 75 Years

Inclusion criteria

Inclusion criteria: Age 30-75 Diagnosis for Parkinson's disease by Neurologist Diagnosis of depression, mild to moderate according to HAM-D

Exclusion criteria

Exclusion criteria: Age outside the range of 30-75 years Diagnosis or history of other neurological diseases such as epilepsy and Alzheimer's disease Diagnosis or history of vascular disorders, dementia and stroke Diagnosis or history of other psychiatric disorders such as bipolar disorder Addiction Antipsychotic use in the past year Diagnosis of central nervous system infections such as meningitis during the study Use of Linezolid at the beginning of the study, or during the study

Design outcomes

Primary

MeasureTime frame
Severity of depressive and motor symptoms. Timepoint: Weeks 0 - 4 - 8. Method of measurement: By Hamiltion Depression Rating Scale & MDS-UPDRS III.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Shahin Akhondzadeh

Tehran University of Medical Sciences

s.akhond@sina.tums.ac.ir+98 21 5541 2222

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026